![]() Intralipid 20%, 30%: Disturbances in normal fat metabolism such as pathologic hyperlipemia, lipoid nephrosis, or acute pancreatitis if accompanied by hyperlipidemia pharmacy bulk package is not intended for direct IV administrationĬlinolipid, Nutrilipid: Known hypersensitivity to egg or soybean proteins or to any component of the formulation severe hyperlipidemia (serum triglyceride concentrations above 1,000 mg/dL) or severe disorders of lipid metabolism characterized by hypertriglyceridemiaĬanadian labeling: Additional contraindications (not in US labeling): Hypersensitivity to egg, soya or peanut protein or to any component of the formulation acute shock severe hyperlipidemia conditions characterized by severely disordered fat metabolism (eg, severe hepatic impairment, acute MI, hemophagocytotic syndrome, shock) Dosing: Adult Additional data may be necessary to further define the role of intravenous fat emulsion in this setting.īased on the American College of Medical Toxicology (ACMT) Position Statement: Guidance for the Use of Intravenous Lipid Emulsion, the American Society of Regional Anesthesia and Pain Medicine (ASRA), and the American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care, IV fat emulsion given for hemodynamic or other instability secondary to local anesthetics and other highly lipid soluble substances may be considered when the patient does not respond to standard resuscitation measures (eg, fluids, vasopressors, inotropes), ], ] in patients with any local anesthetic systemic toxicity event judged to be potentially serious, lipid emulsion should be administered soon after airway management ]. Off Label Uses Serious hemodynamic or other instability secondary to highly lipid soluble substancesĭata from a limited number of patients studied and case reports suggest that IV fat emulsion may be beneficial for the treatment of serious hemodynamic or other instability not responsive to standard resuscitation measures (eg, fluids, vasopressors, inotropes) secondary to highly lipid soluble substances including, but not limited to: lipophilic local anesthetics, beta blockers, calcium channel blockers, tricyclic antidepressants, cocaine, benzonatate, bupropion, lamotrigine, quetiapine, and venlafaxine, 2009], 2009],, ,, ,, ,, ,, ,, ,, ,, ,, ,,. Related/similar drugs Intralipid, fat emulsion, parenteral nutrition solution, Novamine, cysteine Use: Labeled IndicationsĬaloric/fatty acid source: Source of calories and essential fatty acids for patients requiring parenteral nutrition for extended periods of time (usually for longer than 5 days) or when oral or enteral nutrition is not possible, insufficient, or contraindicated to prevent and treat essential fatty acid deficiency (except Clinolipid and Nutrilipid). Metabolismįatty acids, phospholipids, and glycerol are metabolized by cells to adenosine triphosphate (ATP), carbon dioxide, and water Excretionīiliary (phospholipids) Half-Life Elimination Lipid administration may also affect the heart in a metabolically advantageous way by improving fatty acid transport (Weinberg 2006). High lipid partition constant and large volumes of distribution are good predictors of success when using lipid therapy (French 2011). In toxicity secondary to highly lipid soluble substances, exogenous lipids provide an alternative source of binding (Rowlingson 2008), commonly known as the "lipid sink" effect. ![]() ![]() Detailed Fat emulsion dosage information Brand Names: U.S.įat emulsion is metabolized and utilized as an energy source provides the essential fatty acids, linoleic acid, and alpha linolenic acid necessary for normal structure and function of cell membranes in local anesthetic toxicity, lipid emulsion probably extracts lipophilic local anesthesia from cardiac muscle ![]()
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